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MacDonald Lab Publications

  1. D'Aiuto L, Zhi Y, Kumar Das D, Wilcox MR, Johnson JW, McClain L, MacDonald ML, Di Maio R, Schurdak ME, Piazza P, Viggiano L, Sweet R, Kinchington PR, Bhattacharjee AG, Yolken R, Nimgaonkar VL. Large-scale generation of human iPSC-derived neural stem cells/early neural progenitor cells and their neuronal differentiation. Organogenesis. 2014; 10:365-377. PMID: 25629202.
  2.   MacDonald ML, Ding Y, Newman J, Hemby S, Penzes P, Lewis DA, Yates NA, Sweet RA. Altered glutamate protein co-expression network topology linked to spine loss in the auditory cortex of schizophrenia. Biol Psychiatry. 2015 Jun 77:959-968. PMID: 25433904.
  3. Shelton MA, Newman JT, Gu H, Sampson AR, Fish KN, MacDonald ML, Moyer CE, DiBitetto JV, Dorph-Petersen KA, Penzes P, Lewis DA, Sweet RA. Loss of Microtubule-Associated Protein 2 Immunoreactivity Linked to Dendritic Spine Loss in Schizophrenia. Biol Psychiatry. 2015 Sept 78:374-385. PMID: 25818630.
  4. Wang T, Zhao R, Zhou Fang, Ding Y, MacDonald ML, Sweet R, Chen W#. Fast GGM: An efficient algorithm for the inference of Gaussian graphical model. Plos Computational Biology. 2016 Feb 12(2): e1004755. PMID: 26872036.
  5. Kirkwood CM, MacDonald ML, Schempf TA, Vatsavayi AV, Ikonomovic MD, Koppel JL, Ding Y, Sun M, Kofler JK, Lopez OL, Yates NA, Sweet RA. Altered Levels of Visinin-Like Protein 1 Correspond to Regional Neuronal Loss in Alzheimer Disease and Frontotemporal Lobar Degeneration. J Neuropathol Exp Neurol. 2016 Jan 14 75(2):175-82. PMID: 26769253.
  6. Sweet RA, MacDonald ML, Kirkwood CM, Ding Y, Schempf T, Jones-Laughner J, Kofler J, Ikonomovic MD, Lopez OL, Fitz NF, Koldamova R, Yates NA. APOE*4 genotype is associated with altered levels of glutamate signaling proteins and synaptic co-expression networks in the prefrontal cortex in mild to moderate Alzheimer disease.  Mol Cell Proteomics. 2016 Jul 15(7):2252-62. PMID: 27103636.
  7. MacDonald ML, Alhassa J, Newman JT, Richard M, Hong Gu H, Ryan M. Kelly RM, Alan R, Sampson AR, Kenneth N. Fish KN, Peter Penzes P, Zachary P. Wills ZP, David A. Lewis DA, Robert A. Sweet RA. Selective Loss of Smaller Spines in Schizophrenia. American Journal of Psychiatry. Jun 1;174(6):586-594. PMID: 28359200.
  8. J.M. Krivinko, S.L. Erickson, Y. Ding, Z. Sun, P. Penzes, M.L. MacDonald, N.A. Yates, M.D. Ikonomovic, O.L. Lopez, R.A. Sweet, J. Kofler. Synaptic Proteome Compensation and Resilience to Psychosis in Alzheimer's Disease. Am J Psychiatry. 2018 Oct 1;175(10):999-1009. PMID: 30021459.
  9. Rajarajan P , Borrman T, Liao W , Schrode N, Flaherty E, Casiño C, Powell S, Yashaswini C, LaMarca E, Kassim B, Javidfar B, Espeso-Gil S, Li A, Won H, Geschwind D, Ho SM, MacDonald ML, Hoffman GE, Roussos P, Zhang B, Hahn CG , Weng Z, Brennand KJ, Akbarian S. Neuron-specific Signatures in the Chromosomal Connectome Associated with Schizophrenia Risk. Science. 2018 Dec 14;362(6420). PMID: 30545851.
  10. MacDonald ML, Favo D, Garver M, Sun Z, Arion A, Ding Y, Yates N, Sweet RA, Lewis DA. Laser Capture Microdissection – Targeted Mass Spectrometry: A Method for Multiplexed Protein Quantification Within Individual Layers of The Cerebral Cortex. Neuropsychopharmacology. 2019 Mar 44(4):743-748. PMID: 30390066.
  11. Torregrossa MM, MacDonald ML, Stone KL, Lam TT, Nairn AC, Taylor JR. Phosphoproteomic analysis of cocaine memory extinction and reconsolidation in the nucleus accumbens. Psychopharmacology (Berl). 2019 Jan 236(1):531-543. PMID: 30411139.
  12. McKinney BC, MacDonald ML, Newman JT, Shelton MA, DeGiosio RA, Kelly RM, Fish KN, Sampson AR, Lewis DA, Sweet RA. Density of small dendritic spines and microtubule-associated-protein-2 immunoreactivity in the primary auditory cortex of subjects with schizophrenia. Neuropsychopharmacology. 2019 May;44(6):1055-1061. doi: 10.1038/s41386-019-0350-7. 2019 May 44(6):1055-1061. PMID: 30795003.
  13. Nucifora LG, MacDonald ML, Lee BJ, Peters ME, Norris A, Orsburn B, Yang K, Gleason K, Margolis RL, Pevsner J, Tamminga C, Sweet RA, Ross CA, Sawa A, Nucifora FC. Increased protein insolubility in brains from a subset of patients with schizophrenia. American Journal of Psychiatry. 2019 Sep 1;176(9):730-743. PubMed PMID: 31055969.
  14. MacDonald ML, Garver M, Newman J, Sun Z, Kannarkat J, Salisbury R, Glausier J, Ding Y, Lewis DA, Yates N, Sweet RA. Synaptic Proteome Alterations in the Primary Auditory Cortex of Schizophrenia. JAMA Psychiatry. 2020 Jan 1;77(1):86-95. PMID: 31642882.
  15. Grubisha MJ, Sun X, MacDonald ML, Garver M, Sun Z, Paris KA, Patel DS, DeGiosio RA, Lewis DA, Yates NA, Camacho C, Homanics GE, Ding Y, Sweet RA. MAP2 is Hyperphosphorylated in Schizophrenia, Altering its Function. Mol Psychiatry. 2021 Feb 1. doi: 10.1038/s41380-021-01034-z. PMID: 33526823.
  16. Dumrongprechachan V, Salisbury RB, Soto G, Kumar M, MacDonald ML#, Kozorovitskiy Y#. Cell-type and subcellular compartment-specific APEX2 proximity labeling reveals activity-dependent nuclear proteome dynamics in the striatum. Nat Commun. 12, 4855 (2021). PMID: 34381044.
  17. Prado DS, Cattley RT, Shipman CW, Boggess WC, MacDonald ML, Hawse WF. Synergistic and additive interactions between receptor signaling networks drive the regulatory T cell versus T helper 17 cell fate choice. J Biol Chem 2021 Dec;297(6):101330. doi: 10.1016/j.jbc.2021.101330. PMID: 34688667.
  18. Przepiorski A, Vanichapol T, Espiritu EB, Crunk AE, Parasky E, McDaniels MD, Emlet DR, Salisbury R, Happe CL, Vernetti LA, MacDonald ML, Kellum JA, Kleyman TR, Baty CJ, Davidson AJ, Hukriede NA. Modeling oxidative injury response in human kidney organoids. Stem Cell Res Ther. 2022. doi: 10.1186/s13287-022-02752-z. PMID: 35189973
  19. DeChellis-Marks MR, Wei Y, Ding Y, Wolfe CM, Krivinko J, MacDonald ML, López OL, Sweet R, Kofler J. Psychosis in Alzheimer’s Disease is Associated with Increased Excitatory Neuron Vulnerability and Post-Transcriptional Mechanisms Altering Synaptic Protein Levels. Front Neurol. 2022. doi: 10.3389/fneur.2022.778419. PMID: 35309563
  20. Todd NK, Huang Y, Young Lee J, Doruker P, Krieger JM, Salisbury R, MacDonald ML, Bahar I, Thathiah A. GPCR kinases generate an APH1A phosphorylation barcode to regulate amyloid-β generation. Cell Rep. 2022. doi: 10.1016/j.celrep.2022.111110. PMID: 35858570.
  21. Krivinko JM, Erickson SL, MacDonald ML, Garver ME, Sweet RA. Fingolimod mitigates synaptic deficits and psychosis-like behavior in APP/PSEN1 mice. Alzheimers Dement. 2022. doi: 10.1002/trc2.12324. PMID: 36016832
  22. G Huang Y, Guimaraes TR, Todd NK, Ferguson C Weiss KW, Stauffer F, McDermott B, Hurtle BT, Saito T, Saido TC, MacDonald ML, Homanics GE, Thathiah A. protein-biased GPR3 signaling ameliorates amyloid pathology in a preclinical Alzheimer’s disease mouse model. PNAS. In Press.
  23. Dumrongprechachan V, Salisbury RB, Butler L, MacDonald ML#, Kozorovitskiy Y#. Dynamic proteomic and phosphoproteomic atlas of corticostriatal axons in neurodevelopment. Elife. 2022. In Press.