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Core Publications

  1. Liu, Teresa Te-Ying; Grubisha, Melanie Jean;Wendell, Stacy Gelhaus; Liu, Jiayan; Auchus, Richard Joseph; and DeFranco, Donald B.: Opposing effects of COX-2 on ERβ response to 5α-reductase inhibition in prostate epithelial cells.Journal of Biological Chemistry291(28):14747-14760, 2016. PMID: 27226548.
  2. Jeffries, Marisa A.; Urbanek, Kelly; Torres, Lester;Wendell, Stacy Gelhaus; Rubio, Maria E.; and Fyffe-Maricich, Sharyl: ERK1/2 activation in pre-existing oligodendrocytes of adult mice drives new myelin synthesis and enhanced CNS function.J. Neuroscience36(35):9186-9200, 2016. PMID: 27581459. Featured Article “This Week in the Journal”.
  3. Jackson, Laura E.; Kulkarni, Sucheta; Wang, Huabo; Lu, Jie; Dolezal, James M.; Bharathi, Sivakarma S.; Ranganathan, Sarangarajan; Patel, Mulchand S.; Deshpande, Rahul; Alencastro, Frances;Wendell, Stacy G.; Goetzman, Eric S.; Duncan, Andrew W.; and Prochownik, Edward V.:Genetic dissociation of glycolysis and the TCA cycle affects neither normal nor neoplastic proliferation.Cancer Res77(21):5795-5807, 2017. PMID: 28883002.
  4. Menk, Ashley V.; Scharping, Nicole E.; Moreci, Rebecca S.; Zeng, Xue; Guy, Cliff; Salvatore, Sonia; Bae, Heekyong; Xie, Jianxin; Young, Howard A.,Wendell, Stacy Gelhaus; and Delgoffe, Greg M.: Early TCR signaling induces rapid aerobic glycolysis enabling distinct acute T cell effector functions.Cell Reports22(6):1509-1521, 2018. PMID: 29425506.
  5. Du, Tian; Sikora, Matthew J.; Levine, Kevin M.; Tasdemir, Nilgun; Riggins, Rebecca B.;Wendell, Stacy G.; Van Houten, Bennett; and Oesterreich, Steffi. Key regulators of lipid metabolism drive endocrine resistance in invasive lobular breast cancer.Breast Cancer Research20(1):106, 2018. PMID: 30180878
  6. Thapa, Dharendra; Xie, Bingxian; Zhang, Manling; Stoner, Michael W.; Manning, Janet R.; Huckestein, Brydie R.; Edwards, Lia R.,Mullett, Steven J.; McTiernan, Charles F.,Wendell, Stacy G., Jurczak, Michael J.; and Scott, Iain. Adropin treatment restores cardiac glucose oxidation in prediabetic obese mice.Journal of Molecular and Cellular Cardiology129:174-178, 2019. PMID: 30822408
  7. Yu, Qiujun; Tai, Yi-Yin; Tang, Ying; Zhao, Jingsi; Negi, Vinny; Culley, Miranda K.; Pilli, Jyotsna; Sun, Wei; Brugger, Karin; Mayr, Johannes; Saggar, Rajeef; Saggar, Rajan; Wallace, W. Dean; Ross, David J.; Waxman, Aaron B.;Wendell, Stacy G.;Mullett, Steven J.; Sembrat, John; Rojas, Mauricio; Khan, Omar F.; Dahlman, James E.; Sugahara, Masataka; Kagiyama, Nobuyuki; Satoh, Taijyu; Zhang, Manling; Feng, Ning; Gorscan iii, John; Vargas, Sara O.; Haley, Kathleen J.; Kumar, Rahul; Graham, Brian B.; Langer, Robert; Anderson, Daniel G.; Wang, Bing; Shiva, Sruti; Bertero, Thomas; and Chan, Stephen Y.: BOLA3 deficiency controls endothelial metabolism and glycine homeostasis in pulmonary hypertension.Circulation139(19):2238-2255, 2019. PMID: 30759996
  8. McClanahan, Danielle; Yeh, Andrew; Firek, Brian; Zettle, Stacey; Rogers, Matthew; Cheek, Richard; Nguyen, Michelle V.L.; Gayer, Christopher P.;Wendell, Stacy G.;Mullett, Steven J.; and Morowitz, Michael J.: Pilot study of the effect of plant-based enteral nutrition on the gut microbiota in chronically ill tube-fed children.JPEN J Parenter Enteral Nutr43:899-911, 2019. PMID: 30644566
  9. Liu, Chang; Chikina, Maria; Deshpande, Rahul; Menk, Ashley V.; Wang, Ting; Tabib, Tracy; Brunazzi, Erin A.; Vignali. Kate M.; Sun, Ming; Stolz, Donna B.; Lafyatis, Robert A.; Chen, Wei; Delgoffe, Greg M.; Workman, Creg J.;Wendell, Stacy G.; and Vignali, Dario A.A.: Treg cells promote the SREBP1-dependent metabolic fitness of tumor-promoting macrophages via repression of CD8+T cell-derived interferon-γ.Immunity51:381-397 e6, 2019. PMID: 31350177
  10. Marron, Megan M.; Harris, Tamara B.; Boudreau, Robert M.; Clish, Clary B.; Moore, Steven C.; Murphy, Rachel A.; Murthy, Venkatesh L.; Sanders, Jason L.; Shah, Ravi V.; Tseng, George C.;Wendell, Stacy G.; Zmuda, Joseph M.; and Newman, Anne B.: Metabolites associated with vigor to frailty among community-dwelling older black men.Metabolites. 9(5), 83;https://doi.org/10.3390/metabo9050083, 2019. PMID: 31052232
  11. Hawse, William F.; Cattley, Richard T.; andWendell, Stacy G.TCR signal strength regulates acetyl-CoA metabolism via AKT.Journal of Immunology. 203(11):2771-2775, 2019. PMID: 31628154.
  12. Edmunds, Lia; Huckestein, Brydie; Kahn, Mario; Zhang, Dongyan;Wendell, Stacy G.; Shulman, Gerald; and Jurczak, Michael. Hepatic insulin sensitivity is improved in high-fat diet-fed Park2 knockout mice in association with increased hepatic AMPK activation and reduced steatosis.Physiological Reports. 7:e14281, 2019. doi.org/10.14814/phy2.14281. PMID: 31724300.
  13. Winnica, Daniel; Corey, Catherine; Mullett, Steven; Reynolds, Michael; Hill, Gabrielle;Wendell, Stacy G., Que, Loretta; Holguin, Fernando; and Shiva, Sruti: Bioenergetic differences in the airway epithelium of lean versus obese asthmatics are driven by NO and reflected in circulating platelets.Antioxidant and Redox Signaling31:673-686, 2019. PMID: 30608004.
  14. Weisel, Florian J.;Mullett, Steven J.; Elsner, Rebecca F.; Menk, Ashley V.; Luo, Wei; Wilkenheiser, Daniel; Hawse, William F.; Chikina, Maria; Smita, Shuchi; Conter, Laura J.; Joachim, Stephen M.;Wendell, Stacy L.; Winkler, Thomas H.; Delgoffe, Greg M.; and Shlomchik, Mark J. Germinal center B cells utilize only minimal glycolysis but selectively oxidize fatty acids for energy.Nature Immunology. 21:331-342, 2020. PMID: 32066950.
  15. Marron, Megan;Wendell, Stacy G.; Boudreau, Robert; Clish, Clary; Santanasto, Adam; Tseng, George; Zmude, Joseph; and Newman, Anne. Metabolites associated with walking ability among the oldest old from the CHS All Stars study.J Gerontol A Biol Sci Med Sci. 75(12): 2371-2378, 2020.PMID: 31970383.
  16. Marron, Megan M.; Harris, Tamara B.; Boudreau, Robert M.; Clish, Clary B.; Moore, Steven C.; Murphy, Rachel A.; Venkatesh, L. Murthy; Sanders, Jason L.; Shah, Ravi V.; Tseng, George C.;Wendell, Stacy G.; Zmuda Joseph M; and Newman, Anne B. A metabolite composite score attenuated a substantial portion of the higher mortality risk associated with frailty among community-dwelling older adults.Journal of Gerontology: Medical Sciences. Accepted, May, 2020.https://doi-org.pitt.idm.oclc.org/10.1093/gerona/glaa112.
  17. Li, TengFang; Zhang, Zhongqiang; Bartolacci, Joe G.; Dwyer, Gaelen K.; Liu, Quan; Mathews, Lisa R.; Velayutham, Murugesan; Roessing, Anna S.; Lee, Yoojin C.; Dai, Helong; Shiva, Sruti; Oberbarnscheidt, Martin H.; Dziki, Jenna L.;Mullett, Steven J.;Wendell, Stacy G.; Wilkinson, Jay D.; Webber, Steven A.; Wood-Trageser, Michelle; Watkins, Simon C.; Demetris, Anthony J.; Hussey, George S.; Badylak, Stephen F.; and Turnquist, Heth R. Graft IL-33 regulates infiltrating macrophages to protect against chronic rejection.J Clin Invest. 139(10): 5397-5412, 2020. PMID: 32644975.
  18. Bakalov, Veli; Uribe, Laura Isabel Reyes; Deshpande, Rahul; Maloy, Abigail L., Le Moyec, Laurence; Shapiro, Steve D.; Angus, Derek C.; Chang, Joyce;Wendell, Stacy Gelhaus; and Kaynar, A. Murat. Dichloroacetate-induced metabolic reprogramming improves lifespan in a Drosophila model of surviving sepsis.PLoS One. 15(11):e0241122, eCollection 2020. PMID: 33151963.
  19. Watson, McLane J.; Vignali, Paolo D.A.; Mullett, Steven J.; Rittenhouse, Natalie L.; Menk, Ashley V.; Whetstone, Ryan D.; Morrison, Brett M., Rothstein, Jeffrey D., Poholek, Amanda C.; Wendell, Stacy G.; and Delgoffe, Greg M. Metabolic support of tumour-infiltrating regulatory T cells by lactic acid. Nature. 591(7851):645-651, 2021. PMID 33589820.
  20. Houston, Ryan; Sekine, Shiori; Calderon, Michael J.; Seifuddin, Fayaz; Wang, Guanghui; Kawagishi, Hiroyuki; Malide, Daniela A.; Li, Yuesheng; Gucek, Marjan; Pirooznia, Mehdi; Nelson, Alissa J;Mullett, Steven J.; Stokes, Matthew P.; Stewart-Ornstein, Jacob;Wendell, Stacy G.; Watkins, Simon C.; Finkel, Toren; and Sekine, Yusuke. Acetylation-mediated remodeling of the nucleolus regulates cellular acetyl-CoA-responses.PLoS Biology.18(11):e3000981, eCollection 2020 Nov. PMID: 33253182.
  21. Singh, Krishna B.; Hahm, Eun-Ryeong; Kim, Su-Hyeong; Wendell, Stacy G.; and Singh, Shivendra V. A novel metabolic function of Myc in regulation of fatty acid synthesis in prostate cancer. Oncogene. 40:592-602, 2021. PMID: 33199826.
  22. Wang, Dong; Hartman, Robert; Han, Chao; Zhou Chaoming; Couch, Brandon; Malkamaki, Matias; Roginskava, Vera, Van Houten, Bennett; Mullett, Steven;Wendell, Stacy; Jurczak, Micahel; Kang, James; Lee, Joon; Sowa, Gwendolyn; and Nam Vo. Lactate oxidative phosphorylation by annulus fibrosus cells: Evidence for lactate-dependent metabolic symbiosis in intervertebral discs.Arthritis Res Ther. 23(1): 145, 2021.PMID: 34020698.
  23. Opyemi, Oluwasinmisola; Rogers, Matthew; Firek, Brian; Janesko-Feldman, Keri; Vagni, Vincent; Mullett, Steven;Wendell, Stacy; Nelson, Brittany; New, Lee Ann; Marino, Eliana; Kochanek, Patrick; Bayir, Hulya; Clark, Robert; Morowitz, Michael; Simon, Dennis. Sustained dysbiosis and decreased fecal short chain fatty acids after traumatic brain injury and impact on neurological outcome.J Neurotrauma. 38(18):2610-2621, 2021. PMID: 33957773.
  24. Marron, Megan M.; Moore, Steven C.;Wendell, Stacy G.; Boudreau, Robert M.; Miljkovic, Iva; Sekikawa, Akira and Newman, Anne B. Using lipid profiling to better characterize metabolic differences in apolipoprotein E (APOE) genotype among community-dwelling older Black men.GeroScience. 44(2): 1083-1094, 2022. PMID: 33991295.
  25. Marrocco, Antonella; Frawley, Krystin; Pearce, Linda L.; Peterson, James; O`Brien, James P.; Mullett, Steven J.; Wendell, Stacy G.; St. Croix, Claudette M.; Mischler, Steven E.; and Luis A. Ortiz. Metabolic adaptation of macrophages as mechanism of defense against crystalline silica. J Immuol 207(6):1627-1640, 2021. PMID: 34433619 PMCID: PMC8428747.
  26. Houston, Ryan; Sekine, Yusuke; Larsen, Mads B.; Murakami, Kei; Mullett, Steven J.; Wendell, Stacy G.; Narendra, Derek P.; Chen, Bill B.; and Shiori Sekine. Discovery of bactericides as an acute mitochondrial membrane damage inducer. MBoC, 32(21):ar32, 2021. PMID: 34395738.
  27. Bina, Thomas; Kunkle, Dillon; Bina, Xiaowen; Mullett, Steven; Wendell, Stacy and James Bina. Bile salts promote ToxR regulon activation during growth under virulence inducing conditions. Infection and Immunity, 89(12):e0044121, 2021. PMID: 34543121.
  28. Song, Shanshan; Yu, Lauren; Nabiul, Hasan; Paruchuri, Satya; Mullett, Steven J.; Sullivan, Mara L.G.; Fiesler, Victoria M.; Young, Cullen B.; Stolz, Donna G.; Wendell, Stacy G.; and Dandan Sun. Elevated microglial oxidative phosphorylation and phagocytosis stimulate post-stroke brain remodeling and cognitive function recovery in mice. Commun Biol, 5:35, 2022. PMID: 35017668.
  29. Golbourn, Brian J.; Halbert, Matthew E.; Halligan, Katharine; Varadharajan, Srinidhi; Krug, Brian; Mbah, Nneka E.; Kabir, Nisha, Stanton, Ann-Catherine Jean; Locke, Abigail L.; Casillo, Stephanie M.; Zhao, Yahua; Sanders, Lauren; Cheney, Allison; Mullett, Steven J.; Chen, Apeng; Wassell, Michelle; Andren, Anthony; Perez, Jennifer; Jane, Esther P.; Premkumar, Daniel R. David; Koncar, Robert F.; Mirhadi, Shideh; McCarl, Lauren. Chang, Yue-Fang; Wu, Yigen L.; Gatesman, Taylor A.; Cruz, Andrea F.; Zapotocky, Michal; Hu, Baoli; Kohanbash, Gary; Wang, Xiuxing; Vartanian, Alenoush; Moran, Michael F.; Lieberman, Frank; Amankulor, Nduka M.; Wendell, Stacy G.; Morozova-Vaske, Olena; Panigrahy, Ashok; Felker, James; Bertrand, Kelsey C.; Kleinman, Claudia; Rich, Jeremy N.; Friedlander, Robert M.; Broniscer, Alberto; Lyssiotis, Costas; Jabado, Nada; Pollack, Ian F.; Mack, Stephen C.; and Sameer Agnihotri. Loss of MAT2A compromises methionine metabolism and represents a vulnerability in H3K27M mutant glioma by modulating the epigenome. Nat Cancer. 3(5): 629-648, 2022. PMID: 35422502.
  30. Dedong; Mullett, Steven J.; Wendell, Stacy G.; and Partha Biswas. Fungal sensing leads to increased glycolysis of neutrophils by selectively regulating antifungal Glut1 activity. Cell Host Microbe, 30:530-544e6, 2022. PMID: 35316647.
  31. Huang, Changjin; Li, Hui; Powell, Juliana S.; Ouyang, Yingshi; Wendell, Stacy G.; Suresh, Subra; Hsia, K. Jimmy; Sadovsky, Yoel; and David Quinn. Assessing hypoxic damage to placental trophoblasts by measuring membrane viscosity of extracellular vesicles. Placenta, 121:14-22, April, 2022. PMID: 35245720.
  32. Surya P. Pandey, Mackenzie J. Bender, Alex C. McPherson, Catherine M. Phelps, Luzmariel Medina Sanchez, Mohit Rana, Lee Hedden,Kishan A. Sangani, Li Chen, Jake S. Shapira, Magdalena Siller, Chhavi Goel, Elena F. Verdú, Bana Jabri, Steven J. Mullett, Stacy G. Wendell, Aatur D. Singhi, Jeremy S. Tilstra, Joseph F. Pierre, Gavin E. Arteel, Reinhard Hinterleitner and Marlies Meisel. Tet2 deficiency drives liver microbiome dysbiosis triggering Tc1 cell autoimmune hepatitis. Cell Host Microbe, 30(7): 1003-1019, July, 2022. PMID: 35658976.
  33. Xie, Bingxian; Ramirez, Wesley; Mills, Amanda M.; Huckestein, Brydie R.; Anderson, Moira; Pangburn, Martha M.; Lang, Eric Y.; Mullett, Steven J.; Chuan, Byron W.; Guo, Lanping; Sipula, Ian; O`Donnell, Christopher P.; Wendell, Stacy G.; Scott, Iain; Michael Jurczak. Empagliflozin restores cardiac metabolic flexibility in diet-induced obese C57BL6/J mice. Curr Res Physiol. 5: 232-239, 2022. PMID: 35677213, PMCID: PMC9168377.
  34. Cramer, Madeline C.; D`Angelo, William A.; Dewey, Marley J.; Manuel, Allison M.; Mullett, Steven J.; Wendell, Stacy G.; Napierala, Dobrawa; Jiang, Peng; and Stephen F. Badylak. Extracellular vesicles present in bone, blood and extracellular matrix have distinctive characteristics and biological roles. Journal of Immunology and Regenerative Medicine. Volume 18 November 2022