The mission of the Health Sciences Mass Spectrometry Core is to support the University of Pittsburgh research community by providing scientific expertise and state-of-the-art instrumentation for the analysis of small molecules, lipids, and proteins by mass spectrometry.
The Health Sciences Mass Spectrometry Core (The MSC) provides liquid chromatography high resolution mass spectrometry (LC-HRMS) services for metabolomics, lipidomics and proteomics. Our goal is to assist investigators throughout the full lifespan of their projects – from experimental design and sample preparation through statistical analysis and interpretation of datasets. We accommodate projects that range in size from isolated experiments through fee for service work to major ongoing, grant-funded collaborations. Some of our common services include:
- Stable isotope tracing
- Untargeted metabolomics and lipidomics
- Targeted metabolite, protein, and lipid profiling
- Label-free protein quantitation
- TMT multiplexing
- Post translational modification (PTM) analysis
- Thermal proteome profiling
We have working relationships with the Center for Metabolism and Mitochondrial Medicine, the Center for Medicine and the Microbiome, and the Small Molecule Biomarker Core to facilitate highly collaborative research involving metabolism, the microbiome, and quantitative biomarker analysis.