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Gelhaus Lab Publications

  1. Park, Jong-Heum; Gelhaus, Stacy L.; Vendantam, Srilakshmi; Oliva, Andrea L.; Batra, Abhita; Blair, Ian A.; Troxel, Andrea B.; Field, Jeffrey; and Penning, Trevor M.: The pattern of p53 mutations caused by PAH o-Quinones is driven by 8-oxo-dGuo formation while the spectrum of mutations is determined by biological selection for dominance. Chem Res Toxicol 21(5):1039-1049, 2008. PMID: 18489080.
  2. Gelhaus, Stacy L.; Harvey, Ronald G.; Penning, Trevor M.; and Blair, Ian A.: Regulation of benzo[a]pyrene-mediated DNA-and glutathione-adduct formation by 2,3,7,8-tetrachlorodibenzo-p-dioxin in human lung cells. Chem Res Toxicol 24(1):89-98, 2011. PMID: 21028851.
  3. Bhat, Showket; Gelhaus, Stacy L.; Mesaros, Clementina; Vachani, Anil; and Blair, Ian A.: A new liquid chromatography-mass spectrometry method for analysis of urinary 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL). Rapid Commun Mass Spectrom 25(1):115-121, 2011. PMID: 21154658.
  4. Basu, Sankha; Mesaros, Clementina; Gelhaus, Stacy L.; and Blair, Ian A.: Stable isotope labeling by essential nutrients in cell culture (SILEC) for preparation of labeled coenzyme A and its thioesters. Anal Chem 83(4):1363-1369, 2011. PMID: 21268609.
  5. Gelhaus, Stacy L.; Mesaros, Clementina A.; and Blair, Ian A.: Cellular lipid extraction for targeted stable isotope dilution liquid chromatography mass spectrometry analysis. J. Vis Exp Nov 17(57), pii: 3399, 2011. PMID 22127066.
  6. Gelhaus, Stacy L.; Gilad, Oren; Penning, Trevor M.; and Blair, Ian A.: Multidrug resistance protein (MRP) 4 attenuates benzo[a]pyrene-mediated DNA-adduct formation in human bronchoalveolar H358 cells. Toxicol Lett 209(1):58-66, 2012. PMID: 22155354.
  7. Woodcock, Steven; Bonacci, Gustavo; Gelhaus, Stacy L.; and Schopfer, Francisco J.: Nitrated fatty acids: Synthesis and measurement. Free Radic Biol Med 59:14-26, 2013. PMID: 23200809.
  8. Fajt, Merritt L.; Gelhaus, Stacy L.; Freeman, Bruce.; Uvalle, Crystal E.; Trudeau, John B.; Holguin, Fernando; and Wenzel, Sally E.: Prostaglandin D2 pathway upregulation: Relation to asthma severity, control, and TH2 inflammation. J Allergy and Clin Immunol 131(6):1504-1512, 2013. PMID: 23506843.
  9. Delmastro-Greenwood, Meghan; Freeman, Bruce A.; and Wendell, Stacy Gelhaus.: Redox-dependent anti-inflammatory signaling actions of unsaturated fatty acids. Invited Review. Annu Rev Physiol 76:79-105, 2014. PMID: 24161076.
  10. Wendell, Stacy Gelhaus; Baffi, Cindy; and Holguin, Fernando: Fatty acids, inflammation and asthma. Invited Review 2014. J Allergy Clin Immunol 133(5):1255-1264, 2014. PMID: 24613565.
  11. Snyder, Nathaniel W.; Golin-Bisello, Franca; Gao, Yang; Blair, Ian A.; Freeman, Bruce A.; and Wendell, Stacy Gelhaus: 15-oxoeicosatetraenoic acid is a 15-hydroxyprostaglandin dehydrogenase-derived electrophilic mediator of inflammatory signaling pathways. Chem Biol Interact 234:144-53, 2015. PMID: 25450232.
  12. Wendell, Stacy Gelhaus; Golin-Bisello, Franca; Wenzel, Sally; Sobol, Robert; Holguin, Fernando; and Freeman, Bruce: 15-hydroxyprostaglandin dehydrogenase generation of electrophilic lipid signaling mediators from hydroxy omega-3 fatty acids. J Biol Chem 290(9):5868-5880, 2015. PMID: 25586183.
  13. Delmastro-Greenwood, Meghan; Hughan, Kara S.; Vitturi, Dario A.; Salvatore, Sonia R.; Grimes, George; Potti, Gopal; Shiva, Sruti; Schopfer, Francisco J.; Gladwin, Mark T.; Freeman, Bruce A.; and Wendell, Stacy Gelhaus: Nitrite and nitrate-dependent generation of fatty acid nitroalkenes. Free Rad Biol Med, 89:333-341, 2015. PMID: 26385079.
  14. Hughan, Kara S.*; Wendell, Stacy Gelhaus*; Delmastro-Greenwood, Meghan; Helblings, Nicole; Corey, Catherine; Bellavia, Landon; Potti, Gopal; Grimes, George; Goodpaster, Brett; Kim-Shapiro, Daniel; Shiva, Sruti; Freeman, Bruce; and Gladwin, Mark: Conjugated linoleic acid modulates clinical responses to oral nitrite and nitrate. Hypertension 70(3):634-644, 2017. PMID: 28739973. *Co-first authors
  15. Prentice, Kacey J.*; Wendell, Stacy G.*; Liu, Ying; Eversley, Judith A.; Salvatore, Sonia R.; Mohan, Haneesha; Brandt, Sydney L.; Adams, Andrew C.; Wang, X. Serena; Wei, David; FitzGerald, Garret A.; Durham, Timothy B.; Hammond, Craig D.; Sloop, Kyle W.; Skarke, Carsten; Schopfer, Francisco J.; and Wheeler, Michael B.: CMPF, a metabolite formed upon prescription Omega-3 ethyl ester supplementation, prevents and reverses steatosis. EBioMedicine 27:200-213, 2018. PMID: 29290411. *Co-first authors.
  16. Woodcock, Chen-Shan Chen; Huang, Yi; Woodcock, Steven R.; Salvatore, Sonia R.; Singh, Bhupinder; Golin-Bisello, Franca; Davidson, Nancy E.; Neumann, Carola; Freeman, Bruce A.; and Wendell, Stacy G.: Nitro-fatty acid inhibition of triple negative breast cancer cell viability, migration, invasion and tumor growth. J Biol Chem 293(4):1120-1137, 2018. PMID: 29158255. Editor Pick Week of 1/28/18.
  17. Buchan, Gregory; Bonacci, Gustavo; Fazzari, Marco; Salvatore, Sonia; and Wendell, Stacy G.: Nitro-fatty acid formation and metabolism. Nitric Oxide 79:38-44, 2018. Invited Review. PMID: 30006146.
  18. Woodcock, Steven R.; Wendell, Stacy G.; Schopfer, Francisco J.; and Freeman, Bruce A.: Synthesis of an electrophilic keto-tetraene 15-oxo-lipoxin A4 methyl ester via a MIDA boronate. Tetrahedron Lett 59:3524-3527, 2018. PMID: 31379396.
  19. Palliyaguru, Dushani L.; Salvatore, Sonia R.; Schopfer, Francisco J.; Cheng, Xuemei; Zhou, Jingyang; Kensler, Thomas W.; and Wendell, Stacy G.: Evaluation of 2-thiothiazolidine-4-carboxylic acid, a common metabolite of isothiocyanates as a biomarker of cruciferous vegetable intake. Mol Nutr Food Res 63(3):e1801029, 2019. PMID: 30408325.
  20. Wendell, Stacy G.; Fan, Hao; and Zhang, Cheng. G protein-coupled receptors in asthma therapy: pharmacology and drug action. Pharmacol Rev. 72:1-49, 2020. PMID 31767622.
  21. Jobbaby, Soma; Vitturi, Dario A.; Salvatore, Sonia R.; Rowart, Pascal; Emlet, David R.; Ross, Mark; St. Croix, Claudette; Pires, Maria F.; Wendell, Stacy G.; Subramanya, Arohan R.; Straub, Adam C.; Tan, Roderick J.; and Schopfer, Francisco J. Nrf2 activation protects against lithium-induced nephrogenic diabetes insipidus. JCI Insight. 5(1):e128578, 2020.
  22. Palliyaguru, Dushani L.; Yang, Li; Chartoumpekis, Dionysios V.; Wendell, Stacy G.; Fazzari, Marco; Skoko, John J.; Liao, Yong; Oesterreich, Steffi; Michalopoulos, George K.; and Kensler, Thomas W. Sulforaphane diminishes the formation of mammary tumors in rats exposed to 17β-estradiol. Nutrients. 12:2282, July 2020, PMID: 32751496.
  23. O`Brien, James and Stacy G. Wendell. Electrophile modulation of inflammation: a two-hit approach. Metabolites. 10:453, 2020. PMID: 33182676.
  24. Manni, Michelle L.; Heinrich, Victoria A.; Buchan, Gregory J.; O`Brien, James P.; Uvalle, Crystal; Cechova, Veronika; Koudelka, Adolf; Ukani, Dharti; Rawas-Qalaji, Mohamad; Oury, Tim D.; Hart, Renee; Ellgass, Madeline; Mullett, Steven J.; Fajt, Merritt L.; Wenzel, Sally E.; Holguin, Fernando; Freeman, Bruce A.; and Stacy G. Wendell. Nitroalkene fatty acids modulate bile acid metabolism and lung function in obese asthma. Sci Rep, 11: 17788, 2021. PMID: 34493738.
  25. Snyder, Nathaniel W.; O’Brien, James P.; Singh, Bhupinder; Buchan, Gregory; Arroyo, Alejandro D.; Liu, Xiaojing; Bostwick, Anna; Varner, Erika L.; Angajala, Anusha; Sobol, Robert W.; Blair, Ian A.; Mesaros, Clementina; and Stacy G. Wendell. Primary saturation of α,β-unsaturated carbonyl containing fatty acids does not abolish electrophilicity. Chem Biol Interact, 350:109689, December 2021. PMID: 34634267.
  26. O’Donnell, Valerie B.; Schebb, Nils H.; Milne, Ginger L.; Murphy, Michael P.; Thomas, Christopher P.; Steinhilber, Dieter; Wendell, Stacy G.; Kühn, Hartmut; Jakkobsen, Per-Johan; Blair, Ian; Murphy, Robert C.; Freeman, Bruce A.; Brash, Alan R.’ FitzGerald, Garret A. Failure to apply standard limit-of-detection or limit-of-quantitation criteria to specialized pro-resolving mediator analysis incorrectly characterizes their presence in biological samples.
  27. Belyaeva, Olga V.; Wirth, Samuel E.; Boeglin, William E.; Karki, Suman; Goggans, Kelli R.; Wendell, Stacy G.; Popov, Kirill M.; Brash, Alan R.; and Natalia Kedishvili. J Biol Chem, 298:101257, January, 2022. PMID: 34953854.
  28. Carreno, Mara; Pires, Maria F.; Woodcock, Steven R.; Brzoska, Tomasz; Ghosh, Samit; Salvatore, Sonia R.; Chang, Fei; Khoo, Nicholas K.H.; Dunn, Matthew; Connors, Nora; Yuan, Shuai; Straub, Adam C.; Wendell, Stacy G.; Kato, Gregory J.; Freeman, Bruce A.; Ofori-Acquah, Solomon; Sundd, Prithu; Schopfer, Francisco J.; and Dario A. Vitturi. Immunomodulatory actions of a kynurenine-derived endogenous electrophile. Sci Adv, July, 2022. PMID: 35767602.